He was named best male act, best grime act and won best album for Gang Signs & Prayer. The London star broke into the mainstream this year with a number one album and top 10 single, Big For Your Boots.
“Amazing, incredible… You watch the Mobos growing up so this is an honour. I’m so proud. This is dreams come true,” he said after winning.
“Best album… that’s the one I’m proud of the most because I put my life into my album.”
It was a ceremony dominated by male winners, with Stefflon Don the only woman to pick up an award for best female act.
“Even if I wasn’t up for no nominations or awards, this has been an amazing year for me anyway,” she told Newsbeat.
“Just musically it’s been so sick. I’ve actually been on a musical journey and I now understand what it’s like to be an artist. It’s actually not easy.”
Other stars who took home awards were J Hus who won best song for his track Did You See and Giggs who won best hip-hop act.
The best newcomer act award went to south Londoner Dave.
British actor Idris Elba’s paving stone will be embedded at a location in Hackney, London, where the star grew up.
Accepting the award, he paid tribute to the musicians at the event, telling them they were “killing the game”.
“I’m so thankful to share this stage and be here as someone who is paving the way for you guys, I appreciate this,” he said.
“I remember when we used to watch all the big award shows in America and go, ‘Wow I hope we get an award show like that.’
“Well now we’ve got one, and it’s ours and we own it. You lot should be proud.”
Other winners included Mist for best video, Craig David for best R&B/Soul act and Wizkid for best international act.
This was Craig David’s sixth Mobo Award – he won three in 2000, one in 2001 and one more recently in 2016.
Davido won best African act, Damian Marley was named best reggae act, Moses Boyd took home best jazz act and Volney Morgan & New-Ye won best gospel act.
The award ceremony featured performances from the likes of Cardi B, Krept and Konan, Stefflon Don, Yungen and Britain’s Got Talent winner Tokio Myers.
Stars in attendance at the awards – which launched in 1996 and celebrates music of black origin – included rapper Wiley, model Jourdan Dunn and comedian Michael Dapaah, the man behind Big Shaq’s Mans Not Hot.